A 66year-old male presented with swelling of abdomen with discomfort since last one month which is increasing in noticeable amount for 10 days. On examination, huge splenomegaly is present. a. What is the most likely diagnosis? b. Write laboratory findings of your provisional diagnosis c. Describe peripheral blood smear findings with labelled diagram.

A 58 year old man presented with left sided abdominal distension since 6 months. His CBC revealed TLC of 1.5 lakhs/cumm, Hb of 9 gm/dl and platelet count of 3.8 lakhs/cumm. The PBS showed following picture 1. What is your provisional diagnosis? (1) 2. Mention 3 important bone marrow findings in this disease. (3) 3. Mention two important confirmatory investigations for the diagnosis. (2) 4. Describe the etiopathogenesis behind the usage of targeted therapy. (4)

Chronic Myeloid Leukemia (CML)

A 40 years male presents with h/o fatigue and weight loss for 6 months. O/E pallor, marked splenomegaly+, laboratory report shows Hb 10 gm%, TLC 215,000/cmm, platelets 5 lakhs/ cmm. Differential count shows various immature forms of myeloid series of cells. Answer the following: · What is your diagnosis? · What is common genetic abnormality? · What will be the blood and bone marrow findings of the disease? · Write about various phases of the disease?