23 years female presented with oral ulcers, mallar rash, photosensitivity and non-erosive arthritis involving both knees. Laboratory investigations show persistent proteinuria and leucopenia. a) Write your probable diagnosis? (2 Marks) b)Explain pathogenesis of the disease. (5 Marks) c)Write investigative approach. (5 Marks)

25 years female presented with malar rash on the face, fever, painful joints of fingers. On examination she has tenderness in small joints of both hands without deformity. Laboratory investigations reveals pancytopenia, urine routine- hematuria and proteinuria, and ANA ++ a) What is your probable diagnosis? Give reasons. 2 mark b) Write about the pathogenesis of the disease? 5mark c) Write in brief about central and peripheral tolerance. 3 mark

A 20 year old female presents with mild anaemia, malar skin rash, arthralgia with nephrotic range proteinuria. a. What is the most probable diagnosis? b. Name important serological investigations for it’s diagnosis. c. Write complications of your diagnosis. d. Write important etiopathogenesis of the diagnosis.